[HTML][HTML] Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a …
Oxidation of low density lipoprotein (LDL) may be of critical importance in triggering the
pathological events of atherosclerosis. Myeloperoxidase, a heme protein secreted by
phagocytes, is a potent catalyst for LDL oxidation in vitro, and active enzyme is present in
human atherosclerotic lesions. We have explored the possibility that reactive intermediates
generated by myeloperoxidase target LDL cholesterol for oxidation. LDL exposed to the
myeloperoxidase-H 2 O 2-Cl− system at acidic pH yielded a family of chlorinated sterols …
pathological events of atherosclerosis. Myeloperoxidase, a heme protein secreted by
phagocytes, is a potent catalyst for LDL oxidation in vitro, and active enzyme is present in
human atherosclerotic lesions. We have explored the possibility that reactive intermediates
generated by myeloperoxidase target LDL cholesterol for oxidation. LDL exposed to the
myeloperoxidase-H 2 O 2-Cl− system at acidic pH yielded a family of chlorinated sterols …
